A 12-Year Retrospective Study of Survival Rates and Outcomes of Very Low Birth Weight Infants in a Single Center.

Jeong,  Moon Sun; Yoon,  Seok Ho; Lee,  Yeon Kyung; Ko,  Sun Young; Shin,  Son Moon

doi:2016.23.1.1

Neonatal Med > Volume 23(1); 2016 > Article

Original Article

Neonatal Medicine 2016;23(1):1-7.
DOI: https://doi.org/10.5385/nm.2016.23.1.1 Published online February 29, 2016.

A 12-Year Retrospective Study of Survival Rates and Outcomes of Very Low Birth Weight Infants in a Single Center.

Moon Sun Jeong, Seok Ho Yoon, Yeon Kyung Lee, Sun Young Ko, Son Moon Shin

Department of Pediatrics, Cheil General Hospital & Women's Health Care Center, Dankook University College of Medicine, Seoul, Korea. ykleeped@hanmail.net

Abstract

PURPOSE
To investigate the outcomes and survival rates of very low birth weight infants (VLBWI) born over a 12-year period in a single center.
METHODS
A retrospective review of 613 VLBWI born from January 2000 to December 2011 was performed. We compared the incidence, survival rate, and morbidity of infants classified according to their birth weight or gestational age for the following periods: Period I (2000-2002), Period II (2003-2005), Period III (2006-2008), and Period IV (2009-2011).
RESULTS
The incidence of VLBWI was 0.7%, while the overall survival rate was 94.9%. The survival rates were 92.8%, 92.9%, 95.9%, and 97.5% for periods I, II, III and IV, respectively; the rates improved significantly over time (P<0.05). The average survival rate of extremely low birth weight infants was 85.9%, and it tended to increase over successive periods (P=0.06). The overall incidence of respiratory distress syndrome was 63.6%; patent ductus arteriosus; 43.6%; bronchopulmonary dysplasia, 30.5%; retinopathy of prematurity (> or =grade III), 8.5%; sepsis, 6.5%; cystic periventricular leukomalacia, 3.8%; necrotizing enterocolitis (> or =grade II), 3.4%; and intraventricular hemorrhage (> or =grade III), 2.3%. A significant decrease was seen in some clinical parameters: the time to start feeding, duration of parenteral nutrition, and duration required to reach full enteral feeding in every successive three-year period (P<0.01).
CONCLUSION
The overall survival rate of VLBWI born between January 2000 and December 2011 was 94.9%. This survival rate was found to increase significantly in each successive three-year period starting January 2000.

Key Words: Infant; Very low birth weight; Outcome