eISSN 2287-9803 
pISSN 2287-9412 
Aims and Scope
Ethical Guidelines
연구출판윤리규정
Editoral Board
Forthcomming Issue
Current Issue
Archive
Search
Most Read Articles
Informaion for Authors
e-Submission
Check List
Contact us
Review Article
  |     |   J Korean Soc Neonatol._19_1_10_16.pdf
J Korean Soc Neonatol. February;19(1):10-16.
Published online 2012 February 28   doi: https://doi.org/10.5385/jksn.2012.19.1.10
Copyright ⓒ 2012 The Korean Society of Neonatology Neonatal Medicine
Probiotics and Necrotizing Enterocolitis
Hyun-Seung Jin
Department of Pediatrics, Gangneung Asan Hospital, College of Medicine, Ulsan University, Gangneung, Korea
Corresponding Author: Hyun-Seung Jin , Tel: +82-33-610-3168 , Fax: +82-33-641-8148 , Email: childlove72@naver.com
ABSTRACT
Necrotizing enterocolitis (NEC) is the most common serious disease of the gastrointestinal tract in preterm infants. Although the pathogenesis of NEC is completely unknown, enteral bacterial growth plays in such disease. The immature development of the preterm gut and the exposure to the neonatal intensive care unit environment along with associated treatments promotes inappropriate intestinal colonization with a predominance of pathogenic organisms. Probiotics are the dietary supplements, containing potentially beneficial bacteria or yeast and may offer potential benefits for preterm infants by increasing mucosal barrier function, improving nutrition, up-regulation of the immune system, reducing mucosal colonization by potential pathogens, and altering the key components of intestinal inflammation. Large randomized controlled trials have shown its effectiveness in the probiotics of the prophylaxis for NEC and mortality. However, important questions remain in establishing the clinical applications for the probiotics, including the optimal duration of administration as well as preferred probiotics dose and species. Further, there is a need to understand the interaction of the probiotics and gut. More additional clinical studies are needed to determine the safety and efficacy of the probiotics in the prophylaxis of NEC.
Keywords: Probiotics, Necrotizing enterocolitis, Premature, Intestine
Copyright(c) By Korean Society of Neonatology. All right reserved.
Rm.1207, King's garden 3 Block, 34, Sajik-ro 8-gil, Jongno-gu, Seoul 110-872, Korea. TEL: +82-2-730-1993 FAX: +82-2-730-1994 Email:neonate2002@hanmail.net