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Original Article
  |     |   J Korean Soc Neonatol._18_2_221_227.pdf
J Korean Soc Neonatol. November;18(2):221-227.
Published online 2011 November 25   doi: https://doi.org/10.5385/jksn.2011.18.2.221
Copyright ⓒ 2011 The Korean Society of Neonatology Neonatal Medicine
Identification of Characteristics and Risk Factors Associated with Mortality in Hydrops Fetalis
Hoon Ko, M.D., Byong Sop Lee, M.D., Ki Soo Kim, M.D., Hye Sung Won, M.D.*, Pil Ryang Lee, M.D.*, Jae Yoon Shim, M.D.*, Ahm Kim, M.D.*, and Ai-rhan Kim, M.D.
Department of Pediatrics, Division of Neonatology, Asan Medical Center, Children’s Hospital, University of Ulsan College of Medicine, Seoul, Korea
Department of Obstetrics and Gynecology*, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Corresponding Author: Ai-rhan Kim, M.D. , Tel: +82-2-3010-3382 , Fax: +82-2-3010-6978 , Email: arkim@amc.seoul.kr
ABSTRACT
Purpose: The objectives were to identify the characteristics of neonates with hydrops fetalis, and to identify the risk factors associated with mortality. Methods: A retrospective review of AMC (Asan Medical Center) dataset was performed from January 1990 to June 2009. The characteristics of 71 patients with hydrops fetalis were investigated and they were divided into two groups: the survived group and the expired group. Various perinatal and neonatal factors in two groups were compared to find out risk factors associated with mortality based on univariate analysis, followed by multiple regression analyses (SPSS version 18.0). Results: Of those 71 neonates (average gestational age: 33 weeks, birth weight: 2.6 kg), 38 survived, 33 died, resulting in overall mortality rate of 46.5%. The most common etiology was idiopathic followed by chylothorax, cardiac anomalies, twin-to-twin transfusion, meconium peritonitis, cardiac arrythmias, and congenital infections. Factors that were associated independently with mortality in logistic regression analyses were low 5-minutes Apgar score, hyaline membrane disease and delayed in achieving 50th percentile ideal body weight for appropriate gestational age by 10 days. Conclusion: In this study, 5-minutes Apgar score, hyaline membrane disease and delayed in achieving 50th percentile ideal body weight for appropriate gestational age by 10 days were significant risk factors associated with mortality in hydrops fetalis. Therefore, the risk of death among neonates with hydrops fetalis depends on the illness immediately after birth and severity of hydrops fetalis. Informations from this study may prove useful in prediction of prognosis to neonates with hydrops fetalis.
Keywords: Hydrops fetalis, Mortality, Risk factor
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