A Case of Hemolytic Disease in the Newborn Due to Anti-Dia Antibody.

Chung,  Min A; Park,  Eun Hye; Lee,  Chang Han; Oh,  Chang Hee; Namgung,  Ran; Kim,  Hyun Ok; Park,  Min Soo; Park,  Kook In; Lee,  Chul; Han,  Dong Gwan

Case Report

Journal of the Korean Society of Neonatology 2001;8(1):141-144.
Published online May 1, 2001.

A Case of Hemolytic Disease in the Newborn Due to Anti-Dia Antibody.

Min A Chung, Eun Hye Park, Chang Han Lee, Chang Hee Oh, Ran Namgung, Hyun Ok Kim, Min Soo Park, Kook In Park, Chul Lee, Dong Gwan Han

¹Department of Pediatrics, College of Medicine, Yonsei University.
²Department of Clinical Pathology, College of Medicine, Yonsei University.
³Department of Pediatrics, Kangnam Sacred Hospital, College of Medicine, Hallym University, Seoul, Korea.

Anti-Dia에 의한 신생아 용혈성 질환 1례

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Abstract

The Diego blood group is expressed as Dia antigen and Dib antigen. The frequency of Dia antigen expression in Korean is estimated to be 6-15%. We report the first case of severe hemolytic disease caused by anti-Dia antibody in Korea. Full-term male infant was admitted due to hyperbilirubinemia on the first day of life. Total bilirubin level was elevated to 20 mg/dL at 20 hours of age and exchange transfusion was performed. Total bilirubin decreased to 12.7 mg/dL after exchange transfusion, but increased to 19.0 mg/ dL at 43 hours of age. After second exchange transfusion, total bilirubin was 6.0 mg/dL. The blood group of mother was type A, Rh D (+ and that of newborn was type O, Rh D (+. The direct antiglobulin test showed strong positive, and anti-Dia antibody was eluted from the baby's red blood cell. Due to higher incidence of Dia antigen expression in oriental population, we suggest that the Diego positive cell panel should be included in the diagnosis of hemolytic disease of the newborn.

Key Words: Anti-Dia antibody; Hemolytic disease of the newborn