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Journal of the Korean Society of Neonatology 2003;10(2):133-142.
Published online November 1, 2003.
Recent Outcome of Extremely Low Birth Weight Infants at Asan Medical Center.
Jin Taek Kim, Hyun Kyung Park, Nu Lee Jun, Jae Woo Lim, Ellen Ai Rhan Kim, Ki Soo Kim, Soo Young Pi
Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. kskim@amc.seoul.kr
초극소 저출생 체중아의 단일 기관에서의 최근 치료 성적
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Survival rate of infants weighing less than 1, 000 g has been increased due to advanced neonatal care. We evaluated the outcome of extremely low birth weight (ELBW) infants who were born at Asan Medical Center. METHODS: We retrospectively reviewed survival, morbidities, and catch-up growth of the 105 ELBW infants from 1999 to 2002. RESULTS: Overall survival rate of ELBW infants was 65.7%. In respect to birth weight, the survival rates for <600 g, 600-699 g, 700-799 g, 800-899 g, 900-999 g were 22.2%, 38.5%, 64.3%, 70.4%, 89.3%, respectively. According to gestational age, <25 week, 25-27 week, 28-30 week, 31-33 weeks by gestational age, the survival rates were 26.7%, 68.3%, 76.9%, 100%, respectively. The mortality was 41.7% within one week of life. Among ELBW survivors, durations of hospitalization, O2 supply, and ventilatory support were 92.2+/-23.9 day, 36.9 +/- 26.5 day, 24.8 +/- 20.3 day, respectively. The incidences of respiratory distress syndrome, chronic lung disease and patent ductus arteriosus were 52.2%, 68.1%, 47.8%, respectively. The incidences of severe intraventricular hemorrhage > or = grade III, periventricular leukomalacia, severe retinopathy of prematurity > or = stage III and clinical or proven sepsis were 8.7%, 4.3%, 47.8%(n=33), 69.6%, respectively. 29 infants required laser photocoagulation due to retinopathy of prematurity. Duration of total parenteral nutrition (TPN) was 44.0 +/- 22.3 days. The incidences of TPN-associated cholestasis and necrotizing enterocolitis were 34.8%, 7.2%, repectively. At 18 months, 78.3% of ELBW infants showed catch-up growth. CONCLUSION: Survival rate of ELBW infants was 65.7%, which was much improved but lower than that of western and Japanese outcome. Further efforts must be made to increase their survival rates and to reduce morbidities.
Key Words: Extremely low birth weight (ELBW); Survival rate; Morbidity


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