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Neonatal Med > Volume 18(1); 2011 > Article
Journal of the Korean Society of Neonatology 2011;18(1):49-58.
DOI: https://doi.org/10.5385/jksn.2011.18.1.49    Published online May 15, 2011.
Cord Blood Adiponectin and Insulin-like Growth Factor-I in Term Neonates of Gestational Diabetes Mellitus Mothers: Relationship to Fetal Growth.
Jin A Sohn, Eun Ae Park, Su Jin Cho, Young Ju Kim, Hyesook Park
1Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea. pea8639@ewha.ac.kr
2Department of Obstetrics, Ewha Womans University School of Medicine, Seoul, Korea.
3Department of Preventive Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
The purpose of this study was to evaluate the relationship between cord blood adiponectin and insulin-like growth factor (IGF)-I and their effect on fetal growth and insulin resistance in mothers with gestational diabetes mellitus (GDM).
Cord blood adiponectin and IGF-I were compared between mothers with GDM (GDM group, N=53) and controls (non-GDM group, N=101). Neonates were classified into three groups of small for gestational age (SGA, N=26), appropriate for gestational age (AGA, N=97), and large for gestational age (LGA, N=31) by birth weight. The association between cord adiponectin and IGF-I levels was evaluated in relation to maternal and neonatal clinical data.
Cord adiponectin was lower in the GDM group than in the non-GDM group (P<0.001). There was no significant difference in cord adiponectin among the SGA, AGA, and LGA groups in the GDM group (P=0.228). The cord adiponectin of AGA in the GDM group was significantly lower than that in the non-GDM group (P<0.001). The most powerful predictor affecting cord adiponectin was the result of maternal 75 g oral glucose tolerance test. The cord IGF-I values between the GDM group and the non-GDM group were not different (P=0.834). Neonates with the heavier birth weight had the higher cord IGF-I levels. The most powerful predictor affecting cord IGF-I was birth weight and the next was maternal parity.
Both cord blood adiponectin and IGF-I were associated with fetal growth, but IGF-I was a more general and direct factor affecting fetal body size, and adiponectin seemed to have more association with insulin sensitivity than growth.
Key Words: Adiponectin; Insulin-like growth factor-I; Cord blood; Gestational diabetes mellitus
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