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Neonatal Med > Volume 20(1); 2013 > Article
Neonatal Medicine 2013;20(1):97-105.
DOI: https://doi.org/10.5385/nm.2013.20.1.97    Published online March 8, 2013.
Follow-up of Full-term Neonatal Seizures: Prognostic Factors for Neurodevelopmental Sequelae.
Soo Jung Lim, Ja Kyung Jun, Young Ah Youn, Chung Joon Moon, Soon Ju Kim, Ju Young Lee, Hyun Seung Lee, Jung Hyun Lee, So Young Kim, In Kyung Sung
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. sinky@catholic.ac.kr
Abstract
PURPOSE
The objectives of this study were to observe the major neurodevelopmental sequelae of the full-term neonatal seizures, and to identify the risk factors associated with the poor neurodevelopmental outcomes.
METHODS
A retrospective review of the medical records of full-term newborns who had clinical and/or electrographic seizures in neonatal intensive care unit of St. Mary's Hospital between June 1994 to July 2007 was performed. To assess the risk factors associated with poor neurological outcome, various factors were analyzed with univariate analysis and multiple regression analysis (SAS for Windows version 9.2).
RESULTS
The most common etiology of seizures in full-term infants was hypoxic ischemic encephalopathy (76.2%). The most common type of seizure was subtle (50.9%), followed by multifocal clonic (41.8%), and the seizure type had no significant correlation to the prognosis. Moderate to major EEG abnormalities were significantly related to poor clinical outcome. Additional factors related to neurodevelopmental outcome were Apgar score at five minute, evidence of HIE on brain MRI, Sarnat stages of HIE, number of anticonvulsant drugs used for seizure control and duration for normalization of EEG abnormalities.
CONCLUSION
The risk factors observed in this study may be helpful to predict the neurological outcomes in full-term neonates with seizures.
Key Words: Newborn; Seizures; Outcome; Risk factor
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