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Journal of the Korean Society of Neonatology 1998;5(2):158-166.
Published online January 1, 2001.
Hematologic Characteristics of Neonates Born to Pregnancy-Induced Hypertensive Mothers.
Hye Sun Yoon, Sung Jong Park, EIIen A Kim, Ki Soo Kim, Soo Young Pi
Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
To determine clinical and hematological characteristics of infants born to pregnancy-induced hypertensive mothers and whether neutropenia in these infants is associated with an increased incidence of neonatal sepsis.
A retrospective study was conducted from June 1995 to June 1997 in 84 infants of pregnancy-induced hypertensive mothers who were admitted to the neonatal intensive care unit of Asan Medical Center. These infants were divided into 2 groups according to their absolute neutrophil counts(Group I: with neutropenia, Group II: without neutropenia) and their clinical, hematological and maternal characteristics were compared between these groups.
1) Infants in Group I were smaller, younger, and delivered more by cesarean section than in infants in Group II. 2) Neutropenia was observed in 77,7% of infants who were less than 30 weeks of gestational age and less than 1,500 g. Neutropenia and thrombocytopenia seem to be a transient phenomenon improving spontaneously approximately after 5.8 days and 8-10 days, respectively. 3) Sex, 1 min apgar score, type of delivery and initial use of antibiotics differ between these 2 groups. 4) There was no apparent increased risk for development of neonatal sepsis associated with neutropenia.
Neutropenia and thrombocytopenia were observed in 40-50% infants born to pregnancy-induced hypertensive mothers. Such finding was more pronounced in infants whose gestational age was less than 32 weeks and birth weight was less than 1,500 g occuring at 70-80%. Neutropenia, per se, is not associated with increased incidence of sepsis but changes in hematological findings and clinical evidence is more important in predicting sepsis in these infants.
Key Words: Pregnancy induced hypertension; Neonatal neutopenia; Neonatal thrombocytopenia


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