| A Case of Alloimmune Neonatal Neutropenia. |
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Yong Hee Lee, Ji Eun Lee, Jun Ho Huh, Oh Hyuk Kwon, Ae Suk Kim |
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Department of Pediatrics, Pohang St. Mary's Hospital, Pohang, Korea. |
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| Abstract |
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Alloimmune neonatal neutropenia (ANN) is due to maternal IgG neutrophil-specific antibodies that cross the placenta to sensitize fetal neutrophils and cause neutropenia in the neonate. Infection appears within a few days of life.
Neutropenia worsens during the very first days of life and persists until 20-50 days in spite of the disappearance of detectable antibody in the infant's serum. We report a case of ANN in female neonate who was admitted on the 5th day of life due to poor oral intake. The diagnosis was made by indirect immunofluorescence with fluorescein-tagged antihuman globulin reagent. The patient was treated successfully with systematic intravenous antibiotics and highdose intravenous immunoglobulin (IVIG). |
| Key Words:
Alloimmune neonatal neutropenia; IVIG |
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