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Journal of the Korean Society of Neonatology 1999;6(2):276-279.
Published online January 1, 2001.
A Case of Alloimmune Neonatal Neutropenia.
Yong Hee Lee, Ji Eun Lee, Jun Ho Huh, Oh Hyuk Kwon, Ae Suk Kim
Department of Pediatrics, Pohang St. Mary's Hospital, Pohang, Korea.
Abstract
Alloimmune neonatal neutropenia (ANN) is due to maternal IgG neutrophil-specific antibodies that cross the placenta to sensitize fetal neutrophils and cause neutropenia in the neonate. Infection appears within a few days of life. Neutropenia worsens during the very first days of life and persists until 20-50 days in spite of the disappearance of detectable antibody in the infant's serum. We report a case of ANN in female neonate who was admitted on the 5th day of life due to poor oral intake. The diagnosis was made by indirect immunofluorescence with fluorescein-tagged antihuman globulin reagent. The patient was treated successfully with systematic intravenous antibiotics and highdose intravenous immunoglobulin (IVIG).
Key Words: Alloimmune neonatal neutropenia, IVIG


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