J Korean Soc Neonatol. Search


Journal of the Korean Society of Neonatology 2000;7(2):145-153.
Published online January 1, 2001.
Cystic Periventricular Leukomalacia: Clinical Features in the Development and Neurologic Outcome.
Chun Soo Kim, Sang Lak Lee, Joon Sik Kim
1Department of Pediatrics, Sungkyunkwan University, College of Medicine, Samsung Hospital, Masan, Korea.
2Department of Pediatrics, Keimyung University, College of Medicine, Taegu, Korea.
Cystic periventricular leukomalacia (PVL) remains a significant problem in the premature infant, despite recent advances in neonatal intensive care. This study was undertaken to investigate clinical features in the development and neurologic outcome of cystic PVL.
This study involved 24 newborn infants with cystic PVL on brain ultrasonography who were admitted to Dongsan Medical Center between Jan. 1993 and Aug. 1997. We investigated sex ratio, development rate according to gestational age or birth weight, occurrence sites, risk factors and neurologic sequelae related to cystic PVL.
Most cases with cystic PVL were premature infants. The incidence of cystic PVL was 4.5% in babies less than 32 weeks gestational age, 4.6% in babies less than 1,500 g birth weight and 1.3% in all premature babies. Among 24 cases, 22 cases had bilateral lesions and 2 had unilateral lesion. Two cases among 15 extensive lesions showed expansion of lesion to subcortical white matter and 5 showed microcystic PVL among 9 localized lesions. Occurrence sites of 9 localized lesions were frontal area in 2, parietal area in 5 and occipital area in 2. Neurologic outcome of children with cystic PVL showed cerebral palsy : 68.2%, normal development : 22.7%, epilepsy and hearing defect 9.1%, motor disturbance and visual defect : 4.5% respectively. Types of cerebral palsy showed spastic diplegia : 66.7%, spastic quadriplegia : 20%, spastic hemiplegia and mixed form : 6.7% respectively. Cerebral palsy and other neurologic sequelae developed more highly in extensive or bilateral cystic PVL.
Most children with cystic PVL had development of cerebral palsy or other neurologic deficit. Thus estabilishment of adequate follow-up care program is needed to minimize neurologic sequelae and screening test for early diagnosis of cystic PVL in high risk newborn infants, for example very low birth weight infant.
Key Words: Cystic PVL; Premature infant; Cerebral palsy


Browse all articles >

Editorial Office
34, Sajik-ro 8–gil(King’s Gargen 3 Block 1207), Jongno-gu, Seoul 03174, Republic of Korea
Tel: +82-2-730-1993    Fax: +82-2-730-1994    E-mail: neonate2002@naver.com                

Copyright © 2024 by The Korean Society of Neonatology.

Developed in M2PI

Close layer
prev next