Mortality and Morbidity among Small for Gestational Age Infants in Extremely Low Birth Weight Infants.

Chung,  Eun Soo; Park,  Su Hwa; Whang,  Jong Hee; Choi,  Chang Won; Jang,  Yoon Sil; Park,  Won Soon

Original Article

Journal of the Korean Society of Neonatology 2004;11(2):130-136.
Published online November 1, 2004.

Mortality and Morbidity among Small for Gestational Age Infants in Extremely Low Birth Weight Infants.

Eun Soo Chung, Su Hwa Park, Jong Hee Whang, Chang Won Choi, Yoon Sil Jang, Won Soon Park

Department of Pediatrics, Sungkyunkwan University, College of Medicine, Samsung Medical Center, Seoul, Korea. wspark@smc.samsung.co.kr

초극소 저출생 체중아에서 부당경량아의 사망률과 합병증의 발생 빈도

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Abstract

PURPOSE
This study is to evaluate the effect of intrauterine growth retardation on the mortality and morbidity in extremely low birth weight infants (ELBWI).
METHODS
As retrospectively reviewing 266 ELBWI who were admitted to the neonatal intensive care unit of Samsung Medical Center, the effects of intrauterine growth on mortality and morbidity in ELBWI was assessed by comparing appropriate for gestational age (AGA) ELBWI to small for gestational age (SGA) ELBWI. RESULTS: The number of SGA and AGA infants was 65(24%), 201(76%) respectively. The mean gestational age of the SGA infants (28(+6)+/-2(+3) week) was significantly higher than in the AGA infants (26(+2)+/-1(+3) week) (P<0.001). The mean birth weight of the SGA infants (755+/-173 g) was significantly less than in the AGA infants (830+/-118 g) (P< 0.001). The mortality of the SGA infants (29%) was less than in the AGA infants (33%). However, when adjusted for gestational age, there was no statistically significant difference. The incidence of respiratory distress syndrome of the SGA infants (66%) was significantly lower than in the AGA infants (87%). The incidence of bronchopulmonary dysplasia of the SGA infants (20%) was lower than in the AGA infants (23%). However, when adjusted for gestational age, there were no statistically significant differences. There was no statistically significant association of SGA with intraventricular hemorrhage, retinopathy of prematurity and necrotizing enterocolitis.
CONCLUSION
There was no statistically significant association of intrauterine growth retardation with mortality and morbidity in ELBWI.

Key Words: Small for gestational age; Intrauterine growth retardation; Extremely low birth weight infants; Mortality; Morbidity