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Journal of the Korean Society of Neonatology 2006;13(2):226-232.
Published online November 1, 2006.
Predicting Factors for Neurologic Outcome in Full-term Neonates with Hypoxic-Ischemic Encephalopathy.
Chae Young Yeo, Do Kyun Kim, Sun Hee Kim, Eun Song Song, Young Jong Woo, Young Youn Choi
Department of Pediatrics, Chonnam University Medical School, Gwang Ju, Korea. yychoi@chonnam.ac.kr
만삭아 저산소성 허혈성 뇌증에서 신경학적 예후의 예측인자
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Hypoxic injury during delivery and subsequent ischemic encephalopathy is still remained as one of the important cause of neonatal death and associated with neurologic complication. We investigated the predicting factors for neurologic outcome in full-term hypoxic-ischemic encephalopathy (HIE).
Twenty-two full-term neonates with HIE stage II or III from Jan. 2001 to Dec. 2004 were enrolled. We reviewed the medical records retrospectively including obstetric history, initial pH, creatine kinase (CK), ionized calcium, seizure type and duration, EEG, cranial sonography, CT or MRI, and neurologic outcome.
Among 22 patients, outborn was 86.3%, vaginal delivery 68.2%, and male 72.7%. Regarding the obstetrical events, two-thirds had meconium staining or aspiration and prolonged rupture of membrane. Initial arterial pH, CK and ionized calcium were not significantly different between normal and abnormal neurologic outcome group. All of 5 patients recovered from seizure after more than 5 days had neurologic sequelae (P= 0.008). Eight of 16 cases with abnormal EEG showed abnormal development, and all of 4 cases with normal EEG showed normal development. Eight of 12 cases with abnormal imaging study showed neurologic sequelae, however, all of 10 cases with normal study showed normal outcome (P=0.005).
This study suggests that seizure duration and imaging study are the best predicting factors for prognosis in full-term HIE. Although the EEG finding was not signigicant, the normal finding is expected to have good prognosis. The initial laboratory findings had no prognostic significance because of delayed blood sampling in most patients, who transferred from other hospitals after immediate postnatal resuscitation. We encourage the maternal transport especially when the high-risk delivery is anticipated.
Key Words: Hypoxic-ischemic encephalopathy, Neurologic sequelae


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