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Journal of the Korean Society of Neonatology 2007;14(1):71-77.
Published online May 1, 2007.
Stroke Associated With Protein C and S deficiency in Neonate: Report of two Cases.
Eugene Kim, Eun Young Cha, So Young Kim, Wonbae Lee, In Kyung Sung, Chung Sik Chun
Department of Pediatrics, College of Medicine, Catholic University, Seoul, Korea. sykim@catholic.ac.kr
Protein C와 Protein S 결핍이 동반된 신생아 뇌졸중 2례
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Recently, cases of stroke with inherited disorders of blood coagulation have been reported in children. Deficiency of protein C or S predisposing to a hypercoagulable state has been associated with cerebrovascular disease. We describe here two cases of cerebral infarction in neonates presenting with respiratory distress and seizure respectively. One had decreased protein C and the other was found to have decreased protein C and S. One case had asphyxia as an additional risk factor for stroke. No specific therapy was administered in both cases. They are currently being observed in the outpatient clinic without specific events.
Key Words: Protein S; Protein C; Stroke; Cerebral infarction
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