Correlation of Cord Serum Adiponectin and IGF-I with Fetal Growth in Healthy Term Neonates. |
Ji Young Kim, Su Jin Cho, Hae Soon Kim, Hye Sook Park, Eun Ae Park |
1Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea. pea8639@ewha.ac.kr 2Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Korea. |
제대혈 Adiponectin과 IGF-I이 태아성장에 미치는 영향 |
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Abstract |
PURPOSE The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth. METHODS Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72).
The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI). RESULTS The mean cord serum APN was 29.2+/-10.46 microgram/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001).
The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26+/-21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI. CONCLUSION APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight. |
Key Words:
Adiponectin; Insulin like growth factor-I; Fetal growth |
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