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Journal of the Korean Society of Neonatology 2008;15(2):196-199.
Published online November 1, 2008.
Neonatal Intestinal Pseudo-obstruction Associated with Deficiency of the Interstitial Cells of Cajal in a Premature Infant.
Soo Jung Lee, Woo Ryoung Lee
Department of Pediatrics, School of Medicine, Soonchunhyang University, Seoul, Korea. neolee@hosp.sch.ac.kr
카할세포 결핍과 연관된 미숙아 가성 장폐쇄 1례
The interstitial cells of Cajal are the pacemakers in the gastrointestinal tract that modulate gastrointestinal motility. A case of a neonate with intestinal pseudo-obstruction caused by a decreased number of the interstitial cells of Cajal is presented. A premature male infant born at 32 weeks of gestation showed progressive abdominal distention beginning 3 days after initiation of enteral feeding at 15 days of life. No etiologic factors were identified on radiologic studies, a gastrographin enema, and an intestinal biopsy other than a markedly decreased number of the intestinal cells of Cajal. An ileostomy, followed by repair of the ileostomy was done, which resulted in but a limited improvement of the abdominal gas pattern. Respiratory distress, pancytopenia, and abdominal distention persisted, and the infant expired on 142 days of life.
Key Words: Intestinal pseudo-obstruction, Interstitial cells of Cajal, Premature infant


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