Prognosis and Side Effects of Inhaled Nitric Oxide Treatment in Persistent Pulmonary Hypertension of the Newborn.

Ahn,  So Yoon

doi:2015.22.2.71

Neonatal Med > Volume 22(2); 2015 > Article

Review

Neonatal Medicine 2015;22(2):71-77.
DOI: https://doi.org/10.5385/nm.2015.22.2.71 Published online May 29, 2015.

Prognosis and Side Effects of Inhaled Nitric Oxide Treatment in Persistent Pulmonary Hypertension of the Newborn.

So Yoon Ahn

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. yoon.ahn.neo@gmail.com

Abstract

Inhaled nitric oxide (iNO) is a potent and selective pulmonary vasodilator agent that improves arterial oxygenation and subsequent clinical outcomes for newborn infants with persistent pulmonary hypertension of the newborn (PPHN). Along with beneficial pharmacological properties, iNO also shows toxicological effects. Although the side effects of iNO have not been fully understood, these need to be thoroughly considered and monitored for the safe and effective clinical use of iNO. This article presents a review of the side effects of iNO and short-term and long-term clinical prognosis in newborn infants > or =34 weeks' gestation with PPHN.

Key Words: Nitric oxide; Infant newborn; Persistent fetal circulation syndrome