Risk Factors for Rickets of Prematurity in Extremely Low Birth Weight Infants.

Choi,  Yun Jung; Lee,  Soon Min; Shin,  Jeong Eun; Eun,  Ho Seon; Park,  Min Soo; Park,  Kook In; Namgung,  Ran

doi:2015.22.4.192

Neonatal Med > Volume 22(4); 2015 > Article

Original Article

Neonatal Medicine 2015;22(4):192-197.
DOI: https://doi.org/10.5385/nm.2015.22.4.192 Published online November 30, 2015.

Risk Factors for Rickets of Prematurity in Extremely Low Birth Weight Infants.

Yun Jung Choi, Soon Min Lee, Jeong Eun Shin, Ho Seon Eun, Min Soo Park, Kook In Park, Ran Namgung

Division of Neonatology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. RANNG@yuhs.ac

Abstract

PURPOSE
This study aimed to analyze the risk factors for the development of rickets of prematurity in extremely low birth weight (ELBW) infants.
METHODS
We retrospectively reviewed the data of 57 ELBW infants. Nineteen infants were diagnosed with rickets and 38 infants without rickets were recruited. On radiologic evaluation, 47% of infants had grade I, 37% had grade II, and 16% had grade III rickets.
RESULTS
In ELBW infants with rickets, the durations of oxygen administration, mechanical ventilation, parenteral nutrition, and hospitalization were significantly longer compared to those of the control group. The number of days for achieving an enteral caloric intake of 80 kcal/kg/d and the number of days for regaining birth weight were significantly longer compared to those of the control group. Serial weight changes from birth weight during 8 weeks after birth was significantly lower in the rickets group than in the control group. Retinopathy of prematurity was significantly higher in the rickets group than in the control group. After adjustment for birth weight, rickets of prematurity was correlated with days for regaining birth weight (odds ratio [OR], 1.316; P=0.010), and with weight changes from birth weight at 4 weeks of age (OR, 0.964; P=0.033).
CONCLUSION
In ELBW infants, the risk factors for rickets of prematurity were days for regaining birth weight from birth and the weight changes at 4 weeks of age. Early aggressive nutrition for regaining birth weight earlier may reduce the development of rickets of prematurity.

Key Words: Infants; Premature; Extremely low birth weight; Rickets; Risk factors; Enteral nutrition; Body weight change