Clinical Implication of Surgically treated Abdominoperineal Soild Tumor in the Newborn : A Single-Center Experience.

Cho,  Yong Hoon; Kim,  Soo Hong; Kim,  Hae Young; Han,  Young Mi; Lee,  Na Rae; Bae,  Mi Hye; Park,  Kyung Hee; Byun,  Shin Yun

doi:2018.25.1.23

Neonatal Med > Volume 25(1); 2018 > Article

Original Article

Neonatal Medicine 2018;25(1):23-28.
DOI: https://doi.org/10.5385/nm.2018.25.1.23 Published online February 28, 2018.

Clinical Implication of Surgically treated Abdominoperineal Soild Tumor in the Newborn : A Single-Center Experience.

Yong Hoon Cho, Soo Hong Kim, Hae Young Kim, Young Mi Han, Na Rae Lee, Mi Hye Bae, Kyung Hee Park, Shin Yun Byun

¹Division of Pediatric Surgery, Department of Surgery, Pusan National University School of Medicine, Yangsan, Korea.
²Division of Neonatology, Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea. skybluehym@gmail.com

Abstract

PURPOSE
Abdominoperineal solid tumors presenting in neonates often require surgical intervention during the neonatal period. Although we report our single-center experience, this study would be meaningful to understand the clinical implications of these neoplasms.
METHODS
We retrospectively reviewed and analyzed the clinical data and characteristics of 22 patients (≤28 days old) diagnosed with histopathologically confirmed abdominoperineal solid neoplasms (benign or malignant) after surgical resection.
RESULTS
The mean gestational age and postnatal age at the time of operation were 38.3±1.8 weeks and 13.5±8.3 days, respectively. Most patients (18/22, 81.8%) were diagnosed during antenatal care visits; however, 4 (18.2%) were identified after birth. The mean tumor size was 6.4×5.3 cm (3.5–17.0 cm), and tumors occurred most frequently within the sacrococcygeal region (8/22, 36.4%). Histopathologically, 14 patients (63.6%) demonstrated benign tumors and 8 (36.4%) demonstrated malignant tumors. Germ cell tumors and hepatoblastomas were the most commonly observed tumors. Fortunately, all patients showed a localized pattern of tumor involvement without distant metastasis. No recurrence or mortality was observed during the follow-up period (mean 66.4±44.2 months).
CONCLUSION
Abdominoperineal solid tumors occurring in neonates show variable clinical patterns during the antenatal and postnatal monitoring/screening periods. We conclude that aggressive and multidisciplinary approaches could achieve good clinical results in these patients.

Key Words: Abdominoperineal; Solid tumor; Newborn