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Journal of the Korean Society of Neonatology 2005;12(1):32-41.
Published online May 1, 2005.
Effects of Maeil Human Milk Fortifier on Growth and Bone Mineralization in Preterm Infants.
Jae Eun Yu, Ko Soo Pai, Ju Yeon Ham, Moon Sung Park, Sung Seob Yun
1Department of Pediatrics Ajou University School of Medicine, Suwon, Korea. drparkms@ajou.ac.kr
2Maeil Dairy Industry Co., Ltd.
국내에서 개발된 모유강화제의 미숙아 성장과 골무기질화에 대한 임상효과
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A prospective, controlled trial was conducted to evaluate growth, bone mineralization, and nutritional status receiving preterm human milk supplemented with a newly formulated Maeil human milk fortifier. METHODS: Twenty five fortified human milk-fed and preterm formula-fed infants with a birth weight < 1, 800 g and gestational age <35 weeks, who were born at Ajou University Hospital from March, 2003 through August, 2004 were studied. Growth, biochemical indices of bone mineralization, feeding tolerance, morbidity and wrist X-ray were assessed serially. Total body bone mineral density was measured by dual energy X-ray absorptiometry at 2 and 5months of age. RESULTS: There were no differences in growth, including weight, height and head circumference, between two groups. Serum Ca, P, ALP and other biochemical indices were similar. Although low grade rickets (grade I and II) were occasionally found on wrist X-ray, the rate of occurrence and severity were similar. The bone mineral densities of both group showed no difference.
The fortified human milk-fed infants and preterm formula-fed infants showed no difference in growth, and bone mineralization. This newly formulated Maeil human milk fortifier can be safely used in preterm infants.
Key Words: Human milk fortifier; Growth; Bone mineralization


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