| Effects of Maeil Human Milk Fortifier on Growth and Bone Mineralization in Preterm Infants. |
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Jae Eun Yu, Ko Soo Pai, Ju Yeon Ham, Moon Sung Park, Sung Seob Yun |
1Department of Pediatrics Ajou University School of Medicine, Suwon, Korea. drparkms@ajou.ac.kr
2Maeil Dairy Industry Co., Ltd. |
| 국내에서 개발된 모유강화제의 미숙아 성장과 골무기질화에 대한 임상효과 |
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| Abstract |
PURPOSE
A prospective, controlled trial was conducted to evaluate growth, bone mineralization, and nutritional status receiving preterm human milk supplemented with a newly formulated Maeil human milk fortifier. METHODS: Twenty five fortified human milk-fed and preterm formula-fed infants with a birth weight < 1, 800 g and gestational age <35 weeks, who were born at Ajou University Hospital from March, 2003 through August, 2004 were studied. Growth, biochemical indices of bone mineralization, feeding tolerance, morbidity and wrist X-ray were assessed serially. Total body bone mineral density was measured by dual energy X-ray absorptiometry at 2 and 5months of age. RESULTS: There were no differences in growth, including weight, height and head circumference, between two groups. Serum Ca, P, ALP and other biochemical indices were similar. Although low grade rickets (grade I and II) were occasionally found on wrist X-ray, the rate of occurrence and severity were similar. The bone mineral densities of both group showed no difference.
CONCLUSION
The fortified human milk-fed infants and preterm formula-fed infants showed no difference in growth, and bone mineralization. This newly formulated Maeil human milk fortifier can be safely used in preterm infants. |
| Key Words:
Human milk fortifier; Growth; Bone mineralization |
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