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Journal of the Korean Society of Neonatology 2006;13(1):176-179.
Published online May 1, 2006.
Hyponatremia and Generalized Edema Associated with Ibuprofen Therapy in a Neonate.
So Hee Kim, Eun Young Kim, Sang Kee Park
Department of Pediatrics, College of Medicine Chosun University, Gwangju, Korea. skpark@chosun.ac.kr
과량의 Ibuprofen 복용 후 저나트륨혈증과 전신부종을 보인 신생아 1례
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Ibuprofen is a nonsteroidal anti-inflammatory, analgesic, and antipyretic agent which has used for the treatment of rheumatoid and musculoskeletal disorders. Its side effects have generally been minor; these include dyspepsia, anorexia, nausea and vomiting, constipation, rashes, dizziness, and tinnitus. Ibuprofen is a prostaglandin synthetase inhibitor that is not recommended for neonates. It is pharmacologically similar to indomethacin, which is used to treat symptomatic patent ductus arteriosus in premature infants. We report here a case of a term infant who developed severe hyponatremia and generalized edema associated with the ingestion of an overdose of ibuprofen. The baby made a complete recovery.
Key Words: Ibuprofen; Hyponatremia; Generalized edema; Neonate


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