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Original Article
  |   Neonatal Med_25_1_23_28.pdf
Neonatal Med February;25(1):23-28.
Published online 2018 February 28
Copyright ⓒ 2018 Neonatal Medicine Neonatal Medicine
Clinical Implication of Surgically treated Abdominoperineal Soild Tumor in the Newborn : A Single-Center Experience
Yong-Hoon Cho, Soo-Hong Kim, Hae-Young Kim, Young-Mi Han*, Na-Rae Lee*, Mi-Hye Bae*, Kyung-Hee Park *, and Shin-Yun Byun*
Division of Pediatric Surgery, Department of Surgery, Pusan National University School of Medicine, Yangsan, Korea
Division of Neonatology*, Department of Pediatrics, Pusan National University School of Medicine, Yangsan, Korea
Corresponding Author: Young-Mi Han , Tel: +82-55-360-2180 , Fax: +82-55-360-2181 , Email: skybluehym@gmail.com
ABSTRACT
Purpose: Abdominoperineal solid tumors presenting in neonates often require surgical intervention during the neonatal period. Although we report our single-center experience, this study would be meaningful to understand the clinical implications of these neoplasms. Methods: We retrospectively reviewed and analyzed the clinical data and characteristics of 22 patients (≤28 days old) diagnosed with histopathologically confirmed abdominoperineal solid neoplasms (benign or malignant) after surgical resection. Results: The mean gestational age and postnatal age at the time of operation were 38.3±1.8 weeks and 13.5±8.3 days, respectively. Most patients (18/22, 81.8%) were diagnosed during antenatal care visits; however, 4 (18.2%) were identified after birth. The mean tumor size was 6.4×5.3 cm (3.5–17.0 cm), and tumors occurred most frequently within the sacrococcygeal region (8/22, 36.4%). Histopathologically, 14 patients (63.6%) demonstrated benign tumors and 8 (36.4%) demonstrated malignant tumors. Germ cell tumors and hepatoblastomas were the most commonly observed tumors. Fortunately, all patients showed a localized pattern of tumor involvement without distant metastasis. No recurrence or mortality was observed during the follow-up period (mean 66.4±44.2 months). Conclusion: Abdominoperineal solid tumors occurring in neonates show variable clinical patterns during the antenatal and postnatal monitoring/screening periods. We conclude that aggressive and multidisciplinary approaches could achieve good clinical results in these patients.
Keywords: Abdominoperineal, Solid tumor, Newborn
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