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Original Article
  |   Neonatal Med_24_2_71_76.pdf
Neonatal Med May;24(2):71-76.
Published online 2017 May 31
Copyright ⓒ 2017 Neonatal Medicine Neonatal Medicine
Comparison of Safety of Sedatives Versus General Anesthesia in Laser Therapy for Retinopathy of Prematurity
Yo Han Ho, M.D., Jin Hwa Choi, M.D., Ji Sook Kim, M.D., Se In Sung, M.D., So Yoon Ahn, M.D., Sang Jin Kim, M.D.*, Yun Sil Chang, M.D., and Won Soon Park, M.D.
Departments of Pediatrics and Ophthalmology*, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Corresponding Author: So Yoon Ahn , Tel: +82-2-3410-3537 , Fax: +82-2-3410-0830 , Email: yoon.ahn.neo@gmail.com
ABSTRACT
Purpose: Laser therapy for retinopathy of prematurity (ROP) is commonly performed under general anesthesia (GA). However, the use of GA for laser therapy in neonates who have already undergone invasive ventilation may lead to postoperative complications such as severe apnea or the development of ventilator dependency. This study aimed to examine the safety of administering only sedatives instead of GA in extremely low birth weight (ELBW) infants, who are the usual recipients of laser therapy for ROP.
Methods: Among ELBW infants who were admitted to the neonatal intensive care unit (NICU) at Samsung Medical Center between January and December 2012, we studied 30 patients treated with laser therapy for ROP.
Results: The mean gestational age of the patients was 24.6±1.9 weeks, with a mean birth weight of 646±140 g. The mean age and weight of patients at the time of laser therapy for ROP was 36.3±2.3 weeks and 1,470±423 g. In terms of sedatives, 14 patients (46.7%) were administered chloral hydrate alone, 14 (46.7%) were administered a combination of chloral hydrate and midazolam, one was administered midazolam alone, and one received fentanyl. Prior to laser therapy, 16 patients (53.5%) had established self-respiration, 13 (43.3%) relied on non-invasive ventilation and one patient relied on invasive mechanical ventilation. Following laser therapy, two patients who initially had exhibited self-respiration required respiratory assistance via non-invasive positive pressure ventilation and no patient required intratracheal intubation.
Conclusions: We conclude that the use of sedatives may be safe for ELBW infants who undergo laser therapy for ROP.
Keywords: Retinopathy of prematurity, Laser therapy, Sedatives
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