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Original Article
  |     |   Neonatal Med_20_4_413_421.pdf
Neonatal Med November;20(4):413-421.
Published online 2014 January 15   doi: https://doi.org/10.5385/nm.2013.20.4.413
Copyright ⓒ 2013 Neonatal Medicine Neonatal Medicine
Association of Interleukin-1α-889, β-31, β-511 Polymorphism with Risk of Bronchopulmonary Dysplasia
Jeong Hee Kang, MD, Jung Jin Lee, MD, Sung-Il Cho, MD*, YouJin Choi, MD, Heui Seung Jo, MD, Kyu Hyung Lee, MD
Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea
Graduate School of Public Health*, Seoul National University, Seoul, Korea
Corresponding Author: Heui Seung Jo, MD, PhD , Tel: +82-31-780-5230 , Fax: +82-31-780-5239 , Email: joneona@cha.ac.kr
ABSTRACT
Purpose: Although improvements in neonatal care techniques have increased the survival rate of preterm infants, bronchopulmonary dysplasia (BPD) remains an important factor in neonatal mortality and morbidity. BPD is a multifactorial disease associated with genetic and clinical risk factors related to lung development and perinatal inflammation. Interleukin-1 (IL-1) is a crucial cytokine in the early stages of inflammation. In the present study, we aimed to determine the association between the IL-1 polymorphisms, clinical risk factors, and BPD in preterm infants.
Methods: The study was performed who consented infants born at less than 34 weeks’ gestation. The alleles of the 3 sites of the IL-1 gene (IL-1α-889, IL-1β-31, and IL-1β-511) were determined using Taqman®-based allelic discrimination assays. Clinical data were reviewed from the medical records.
Results: A total of 31 infants with BPD and 73 control infants were enrolled in the study. The gestational age (P=0.001) and birth weight (P=0.001) were lower in the BPD group compared to those in the control group. The incidence of respiratory distress syndrome (RDS; P=0.002), patent ductus arteriosus (P=0.01), and retinopathy of prematurity (P<0.001) was higher in the BPD group compared to that in the control group. The frequency of IL-1α-889TT was higher in the BPD group (6.5% vs. 0.0%, P=0.028) compared to that in the control group. The frequencies of IL-1α-889T, IL-1β-31T, and IL-1β-511T did not differ between the BPD and control groups. In logistic regression analysis, gestational age and RDS were found to be associated with BPD.
Conclusion: IL-1α-889, IL-1β-31, and IL-1β-511 polymorphisms are not associated with the development of BPD in preterm infants.
Keywords: Bronchopulmonary dysplasia, Polymorphism, Interleukin-1
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