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Neonatal Med > Volume 23(1); 2016 > Article
Neonatal Medicine 2016;23(1):35-42.
DOI: https://doi.org/10.5385/nm.2016.23.1.35    Published online February 29, 2016.
The Incidence, Treatment and Risk Factors of Candidiasis in Very Low Birth Weight Infants.
Ha Young Shin, Ji Na Park, Yun Hye Shin, Da Young Yun, Hyun A Park, Jong Hee Hwang
Department of Pediatrics, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. jhhwang@paik.ac.kr
Abstract
PURPOSE
Candidiasis is an important morbidity among very low birth weight infants (VLBWI). There is a little data on the risk factors in VLBWI. This study was done to describe the incidence, treatment, and risk factors of candidiasis in VLBWI.
METHODS
From September 2008 to December 2011, medical records of 130 infants with VLBWI in Inje University Ilsan Paik hospital neonatal intensive care unit (NICU) were reviewed retrospectively. Seventeen infants were diagnosed with candidiasis and treated with antifungal agent. Patients were divided into the candidiasis group (CAN, n=17), the bacterial sepsis group (BAC, n=34), and the non-sepsis group (Non-SEP, n=74). Demographic findings and factors associated with candidiasis were compared between these groups.
RESULTS
The mean gestational age was significantly low in the CAN group, but birth weight was not significantly different between the groups. The maternal demographic findings were not significantly different between the groups. The incidence of respiratory distress syndrome (RDS) is higher in the CAN group compared to these groups (P<0.05). The durations of intubation and central venous line were significantly longer in the CAN group than in the other groups (P<0.05). In the logistic regression analysis, the duration of central venous line is the significant factor for candidiasis (P=0.003, odd ratio: 1.56, 95% confidence interval: 1.39-1.68).
CONCLUSION
The incidence of candidiasis in VLBWI was 13.1 % and the risk factor for candidiasis was longer duration of central venous line in our study.
Key Words: Candidiasis, Very low birth, Infants


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