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Original Article
  |     |   J Korean Soc Neonatol._18_2_234_239.pdf
J Korean Soc Neonatol. November;18(2):234-239.
Published online 2011 November 25   doi: https://doi.org/10.5385/jksn.2011.18.2.234
Copyright ⓒ 2011 The Korean Society of Neonatology Neonatal Medicine
Effect of Prophylactic Ibuprofen in Preterm Infants Less than 1,250 g in Birth Weight
Mun Soo Yeo, M.D., KyungVin Choi, M.D., Hyun Ju Lee, M.D., Hyun Kyung Park, M.D., Chang Ryul Kim, M.D. and In Joon Seol, M.D.
Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea
Corresponding Author: Hyun Ju Lee, M.D. , Tel: +82-2-2290-8397 , Fax: +82-2-2297-2380 , Email: blesslee77@hanmail.net
Purpose: Ibuprofen is used for prevention and treatment of patent ductus arteriosus as an alternative drug of indomethacin in very premature infants. We aimed to determine the effect of prophylactic ibuprofen on patent ductus arteriosus and clinical outcomes in preterm infants less than 1,250 g. Methods: A retrospective review of 39 preterm infants who were admitted to our neonatal intensive care unit from November 2009 to July 2010 was performed. Patients were divided into a prophylactic group (n=13) and a matched historical control group (n=26), where prophylactic ibuprofen were administrated within 24 hours after birth. The rate of ductal closure, side-effects of drug treatment and clinical outcomes were compared between two groups. Results: Comparison of the prophylactic and control groups revealed no significant differences in the rate of ductal closure (69.2% vs 77.7%, P=0.825) and surgical ligation (23.1% vs 30.8%, P=0.719). Occurrence of bowel perforation was more frequent in the prophylactic group than the control group, but was not significant (30.8% vs 11.5%, P=0.194). The frequency of intraventricular hemorrhage (grade≥3) and other outcomes did not differ between the groups. Conclusion: Ibuprofen prophylaxis in preterm infants did not decrease the rate of ductal closure, the need for surgical ligation and the incidence of intraventricular hemorrhage. Further studies are needed to investigate the beneficial effect and associated adverse events attributed to ibuprofen prophylaxis.
Keywords: Patent ductus arteriosus, Ibuprofen, Preterm infants
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