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Neonatal Med > Volume 24(4); 2017 > Article
Neonatal Medicine 2017;24(4):178-181.
DOI: https://doi.org/10.5385/nm.2017.24.4.178    Published online November 30, 2017.
Association of Immunoglobulin G at Birth with Late-Onset Sepsis and Related Mortality in Very Low Birth Weight Infants.
Hye Ri Yun, Jeong Min Shin, Young Mi Yoon, Jae Seok Shin, Ji Hyun Kim, Hannah Cho, Seung Han Shin, Ee Kyung Kim, Han Suk Kim
Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. revival421@snu.ac.kr
Abstract
PURPOSE
We aimed to evaluate the association between immunoglobulin G (IgG) at birth and late-onset sepsis (LoS) in preterm infants.
METHODS
Medical records of very-low-birth-weight infants, born at gestational age <28 weeks, between 2013 and 2016, were retrospectively reviewed. Subjects were divided into two groups based on the occurrence of LoS (LoS vs. non-LoS), and IgG levels at 1 day, and at 2 weeks and 4 weeks after birth were investigated. IgG levels, other perinatal factors, and clinical factors were compared in the two groups. The relationship between IgG levels and mortality among infants in the LoS group was also analyzed.
RESULTS
A total of 105 infants were analyzed after exclusion of cases with early onset sepsis or death at < 72 hours of life. Gestational age in the LoS group was lower than in the non-LoS group (25.0±1.8 vs. 26.3±1.4 weeks, P=0.004). IgG levels at birth were similar between the two groups (236.4±96.4 vs. 282.0±104.7 mg/dL, P=0.078). Multivariate analysis showed that IgG at birth was not an independent risk factor for LoS. In the LoS group, IgG levels at birth were comparable between survivors and cases involving mortality.
CONCLUSION
IgG levels at birth were not associated with the occurrence of LoS in extremely preterm infants.
Key Words: Immunoglobulin G, Extremely preterm infant, Late-onset sepsis, Gestational age


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