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Original Article
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J Korean Soc Neonatol. November;18(2):197-203.
Published online 2011 November 25   doi: https://doi.org/10.5385/jksn.2011.18.2.197
Copyright ⓒ 2011 The Korean Society of Neonatology Neonatal Medicine
Perinatal Outcomes of In Vitro Fertilized Twins in Women of Advanced Age
In Hyuk Chung, M.D., Sungwoo Kim, M.D., Heui Seung Jo, M.D. and Kyu Hyung Lee, M.D.
Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea
Corresponding Author: Heui Seung Jo, M.D. , Tel: +82-31-780-5230 , Fax: +82-31-780-5239 , Email: joneona@cha.ac.kr
Purpose: The purpose of this study is to compare perinatal outcomes between in vitro fertilization (IVF) twins and naturally conceived twins born to women aged 35 years or older and to provide basic information for taking care of IVF twins born to women aged 35 years or older. Methods: We reviewed the records of perinatal and neonatal outcomes in 288 IVF twins and 220 naturally conceived twins born to women aged 35 years or older between January 2001 and December 2010 at CHA Bundang Medical Center. Results: No difference was observed in the maternal ages of mothers giving birth to IVF twins and those giving birth to naturally conceived twins. Gestational ages and birth weights of IVF twins were not different from those of naturally conceived twins. Various perinatal outcomes, including gestational diabetes mellitus, pregnancy-induced hypertension, placenta previa, premature amniotic membrane rupture, and need for a Cesarean section did not differ between the 2 groups. However, the 1-min and 5-min Apgar scores (P=0.019 and P=0.045, respectively) were different between the 2 groups. The incidence of early-onset sepsis was lower in the IVF twins than in the naturally conceived twins (P=0.02). However, the 2 groups did not show any difference in the incidence of respiratory distress syndrome, bronchopulmonary dysplasia, patent ductus arteriosus, necrotizing enterocolitis, intraventricular hemorrhage, and other congenital anomalies. Conclusion: The perinatal outcomes in IVF twins born to women aged 35 years or older were not significantly different from those of naturally conceived twins.
Keywords: Maternal age, Fertilization in vitro, Twins, Perinatal motility
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