eISSN 2287-9803 
pISSN 2287-9412 
Aims and Scope
Ethical Guidelines
연구출판윤리규정
Editoral Board
Forthcomming Issue
Current Issue
Archive
Search
Most Read Articles
Informaion for Authors
e-Submission
Check List
Contact us
Review Article
  |     |   J Korean Soc Neonatol._17_2_155_160.pdf
J Korean Soc Neonatol. November;17(2):155-160.
Published online 2010 November 15   doi: https://doi.org/10.5385/jksn.2010.17.2.155
Copyright ⓒ 2010 The Korean Society of Neonatology Neonatal Medicine
Acid-base Balance and Metabolic Acidosis in Neonates
Byong Sop Lee, M.D., Ph.D.
Division of Neonatology, Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
Corresponding Author: Byong Sop Lee, M.D., Ph.D. , Tel: +82-2-3010-3929 , Fax: +82-2-3010-6978 , Email: mdleebs@amc.seoul.kr
ABSTRACT
Metabolic acidosis is commonly encountered issues in the management of critically ill neonates and especially of preterm infants during early neonatal days. In extremely premature infants, low glomerular filtration rate and immaturity of renal tubules to produce new bicarbonate causes renal bicarbonate loss. Higher intake of amino acids, relatively greater contribution of protein to the energy metabolism and mineralization process in growing bones are also responsible for higher acid load in premature infant than in adult. Despite widespread use of sodium bicarbonate in the management of severe metabolic acidosis, use of sodium bicarbonate in premature infants should be restricted to a reasonable but unproven exception such as ongoing renal loss. Despite concern about the low pH value (<7.2) which can compromise cellular metabolic function, no treatment guideline has been established regarding the management of metabolic acidosis in premature infants. Appropriately powered randomized controlled trials of base therapy to treat metabolic acidosis in critically ill newborn infants are demanding.
Keywords: Acid-base imbalance, Metabolic acidosis, Sodium bicarbonate, Premature infant
Copyright(c) By Korean Society of Neonatology. All right reserved.
Rm.1207, King's garden 3 Block, 34, Sajik-ro 8-gil, Jongno-gu, Seoul 110-872, Korea. TEL: +82-2-730-1993 FAX: +82-2-730-1994 Email:neonate2002@hanmail.net