Candida albicans Brain Abscesses in Extremely Low Birth Weight Infant Treated with Amphotericin B, Flucytosine, and Fluconazole.

Hong,  Yoo Rha; Kim,  Ai Rhan E; Koo,  Hyun Woo; Yoon,  Chong Hyun; Kim,  Ki Soo; Pi,  Soo Young

Case Report

Journal of the Korean Society of Neonatology 2005;12(2):227-232.
Published online November 1, 2005.

Candida albicans Brain Abscesses in Extremely Low Birth Weight Infant Treated with Amphotericin B, Flucytosine, and Fluconazole.

Yoo Rha Hong, Ai Rhan E Kim, Hyun Woo Koo, Chong Hyun Yoon, Ki Soo Kim, Soo Young Pi

¹Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. arkim@amc.seoul.kr
²Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

장기간의 Amphotericin B, Flucytosine, Fluconazole 투여로 완치된 초극소 저출생 체중아의 Candida albicans에 의한 다발성 뇌농양

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Abstract

Systemic candidiasis in premature infants often involves the central nervous system (CNS) but only a few reported cases of candidiasis involving the brain parenchyma were found in a recent search of the literature and there is no uniformly accepted approach for treatment of CNS Candida infection in neonates. We report a case of extremely low birth weight infant who had candiduria and Candida meningitis with multiple abscesses formation in brain parenchyma who was successfully treated with long term amphotericin B, flucytosine, and fluconazole therapy without surgical drainage.

Key Words: Extremely Low Birth Weight Infant; Candida albicans; Brain Abscess