J Korean Soc Neonatol. Search

CLOSE


Neonatal Med > Volume 19(4); 2012 > Article
Journal of the Korean Society of Neonatology 2012;19(4):195-203.
DOI: https://doi.org/10.5385/jksn.2012.19.4.195    Published online December 25, 2012.
Seasonal Variations of Respiratory Syncytial Virus Infection among the Children under 60 Months of Age with Lower Respiratory Tract Infections in the Capital Area, the Republic of Korea, 2008-2011.
Kyu Hee Park, Jeong Hee Shin, Eun Hee Lee, Won Hui Seo, Yun Kyung Kim, Dae Jin Song, Byung Min Choi, Ji Tae Choung, Young Sook Hong
1Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. cbmin@korea.ac.kr
2Department of Pediatrics, Kangnam Cha Medical Center, Seoul, Korea.
Abstract
PURPOSE
Palivizumab prophylaxis has been used in the high risk groups of respiratory syncytial virus (RSV) infections, especially with the prematures, infants with chronic lung diseases or hemodynamically significant congenital heart disease. Substantial variations in timing of RSV outbreaks presents a challenge for the optimized use of palivizumab prophylaxis. This study investigates the epidemiologic characteristics of RSV associated lower respiratory tract infections (LRTI) in children, to help guide in the application of palivizumab prophylaxis in the Republic of Korea.
METHODS
This was a retrospective observational study. We performed RSV culture or multiplex RT-PCR from children under 60 months of age admitted for LRTI at three hospitals in the capital area of Korea from May 2008 to April 2011. The study identified RSV infection and analyzed the RSV detection rates.
RESULTS
RSV detection rate was 18.8% (1,721/9,178). The RSV season of 2008-2009 is from the second week of August to the fourth week of March and, that of 2009-2010 is from the first week of October to the third week of Apirl and that of 2010-2011 is from the third week of September to the third week of March. The RSV detection rate in preterms and low birth weight infants were significantly higher during the RSV season and non-RSV season.
CONCLUSION
The RSV seasons were shown to have variations in onset, offset, and durations in each year. Physicains should determine the timing of the first and final doses of palivizumab on the basis of information about the RSV season in their own area. The real-time surveillance systems to analyze the variations of RSV seasons are necessary for the effective and economical preventions of RSV infections in high risk groups.
Key Words: Respiratory syncytial virus, Seasonal variation, Detection rate, Palivizumab, Lower respiratory tract infection
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 8 Crossref
  •    
  • 1,381 View
  • 3 Download


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
Rm.1207, King's garden 3 Block, 34, Sajik-ro 8-gil, Jongno-gu, Seoul 03174, Korea
Tel: +82-2-730-1993    Fax: +82-2-730-1994    E-mail: neonate2002@hanmail.net                

Copyright © 2019 by The Korean Society of Neonatology. All rights reserved.

Developed in M2community

Close layer
prev next