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Neonatal Med > Volume 18(2); 2011 > Article
Journal of the Korean Society of Neonatology 2011;18(2):165-176.
DOI: https://doi.org/10.5385/jksn.2011.18.2.165    Published online November 25, 2011.
Alveolar Aspect of Bronchopulmonary Dysplasia.
Chang Won Choi
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. choicw@snu.ac.kr
2Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
Abstract
The pathologic hallmark of new bronchopulmonary dysplasia (BPD) is an arrest in alveolarization and vascular development. Alveoli are the fully mature gas-exchange units and alveolarization denotes the process through which the developing lung attains its fully mature structure. In human, alveolarization is mainly a postnatal event and begins in utero around 35 postmenstrual weeks and continues to 2 postnatal years. Beginning of respiration with very immature lungs as a result of preterm delivery renders the immature lung to be exposed to various injuries such as mechanical stretch, hyperoxia, infection/inflammation and leads to a disruption of normal alveolarization process, which is a main pathologic finding of BPD. Better understanding of the control mechanisms of normal alveolarization process should help us to figure out the pathophysiology of BPD and discover effective preventive or therapeutic measures for BPD. In this review, the pathologic evolution of BPD from 'old' to 'new' BPD, the detailed mechanisms of normal alveolarization, and the factors that disrupt normal alveolarization will be discussed.
Key Words: Bronchopulmonary dysplasia, Alveolarization, Alveoli


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